Some clinical studies have shown detrimental effects of DPP-4 inhibitors on bone [13, 16, 18], with one study showing no effects [110]
This is resulting in failure of oral birth control pills. Lalani advises that people should use alternative methods of birth control when they are using these medications
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Source data are provided with the paper
Furthermore, in a mouse model of non-alcoholic steatohepatitis, further studies indicated that linagliptin improves insulin sensitivity and hepatic steatosis in mice with diet-induced obesity (161) and ameliorates liver inflammation (162)
Taking multiple GLP medicines together can increase the risk of side effects without necessarily improving results