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Tom Gavin Fact-Checker Tom Gavin joined Everyday Health as copy chief in 2022 after a lengthy stint as a freelance copy editor
This timeline matches B12 pharmacokinetics: intramuscular methylcobalamin reaches peak serum concentration at 8-12 hours, but tissue saturation (particularly in the liver and nervous system) occurs over 48-72 hours as the vitamin is transported into cells and converted to active coenzyme forms (Andrs et al., 2018)
Research community discussions often mention 50 to 150 mg per day by mouth and 2.5 to 5 mg per day by subcutaneous injection
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This makes them ideal for individuals with trouble absorbing Vitamin B12 orally, such as those with gastrointestinal issues like Crohns disease or pernicious anemia
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