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taking with food may reduce GI side effects Avoid late evening dosing in patients reporting agitation or insomnia Allow 4-12 weeks for initial pain benefit

Low-FODMAP options that work Proteins: Chicken, turkey, fish, eggs, and firm tofu are all well-tolerated and unlikely to cause additional gas production

When you eat less food, you get less water from food

Different medications in the same class can produce different side effect profiles in the same individual due to variations in receptor binding characteristics, half-life, and metabolism

New multi-agonists are in development, so there may be more brands and variations on the market in the next year or two

Who is a good candidate for GLP-1 pills