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Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin
Additionally, GIPR (glucose-dependent insulinotropic polypeptide receptor) variants affect dual-incretin responses
Pyroptosis is initiated by the cysteine protease caspase-1, which is activated via inflammasome assembly in response to pathogen- or damage-associated signals 3,4
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