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These include both immune-stimulating and immune-suppressing peptides, depending on the therapeutic application

However, the researchers the trial was marked as completed, but in 2016 they cancelled submission of the results never published the results This is a red flag: we dont know if an issue or toxicity was discovered, or if it was simply a business decision

So, I think read the papers

Superoxide anion, in turn, serves to generate other reactive oxygen species (ROS) that kill the phagocytosed microorganisms

Topical gels/creams: Non-invasive but limited absorption

Some people find it embarrassing or physically difficult to insert them properly, and the stigma surrounding the method of action leads some people to reject them out of hand