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The medication starts at a low dose and increases slowly over several weeks

Tirzepatide tapers over multiple half-lives from a roughly five-day half-life

230:639-648 (2009) Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S

Hours 6 to 24 force the heart to compensate Around hour 6 to 8, blood volume starts dropping

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