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Apart from working the GLP-1 pathway like semaglutide, Mounjaro, and Zepbound also activates a different pathway called GIP (glucose-dependent insulinotropic polypeptide)
While Semaglutide GLP-1-based medications (Ozempic and Wegovy) and Tirzepatide-based medications (Mounjaro) share similarities in their mechanisms of action, there are differences too
In general, the prevalence of melanosis coli in a population tends to increase with age.9 However, it has been reported in a child as young as four years of age.10 The author is not aware of any local statistics on this condition, but is of the impression that melanosis coli is by no means uncommon in colonoscopies performed locally
McKenzie S
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