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7 Lower esophageal sphincter abnormalities, increased risk of hiatal hernia, and increased intragastric pressure are other mechanical causes of obesity directly influencing Barretts esophagus and adenocarcinoma

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The more frequent injection site reactions with exenatide once weekly (22%) compared with semaglutide (1.2%) in SUSTAIN-3 could be a consequence of this ( The head-to-head studies within the SUSTAIN and PIONEER programs allow some comparison of the adverse effect profile ( Table 2 )

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