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All authors had full access to the data and all authors had final responsibility for the decision to submit for publication
Dose adjustments are probably not required for simultaneous use of GLP1RAs with oral medications
The takeaway is that context, genetics, and good medical guidance matter
Understanding whether a patient carries predispositions toward stronger or more gradual GLP-1 pathway activation can support a more informed conversation with a provider about expected timelines, tolerance, and potential dose escalation strategies
It has been speculated that the continued use of bethanechol may result from its use in patients who find the option of undergoing urinary catheterisation intimidating & choose to exhaust less invasive treatment options first, or in select patients where it seems to provide a marginal benefit (Gaitonde et al, 2019)
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