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In CRPC, AR signaling upregulates inhibitory immune checkpoints (e.g., B7-H3) and proinflammatory cytokines (e.g., IL-6, TNF-), which recruit immunosuppressive cells and suppress T-cell function

[6] Larazotide Larazotide acetate is a synthetic peptide that specifically targets tight junction regulation

The clinical data suggests this engineering was successful

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Different mechanism, different profile, different use case

Here is the honest boundary, though