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A survey of 483 compounding pharmacies (Johnson et al., Journal of Managed Care & Specialty Pharmacy , 2025) found 11 different tirzepatide concentrations in active use, though four account for 94% of dispensed vials
We now have a breakthrough class of drugs that can achieve profound weight loss equivalent to bariatric surgery, along with the side benefits of reducing cardiovascular risk factors (hypertension and hyperlipidemia), improving glucose regulation, reversing fatty liver, and the many detrimental long-term effects of obesity such as osteoarthritis and various cancers
No matter which medication you choose, its vital to understand that its a tool, not a cure
PMID: 34464955
In the central nervous system, pre-proglucagon and hence GLP-1, GLP-2 and OXM are exclusively found in a small population of nerve cells in the nucleus of the solitary tract
Thats the RDA enough to keep energy metabolism and nerve health intact in a healthy person
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