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Copper peptides offer a different mechanistic profile with a gentler side-effect profile but they aren't drop-in replacements for FDA-approved drugs

PMID: 11225715 Shortened GH peptide (AOD9604) stimulates lipolysis and inhibits lipogenesis both in vitro and in vivo

Sudakova KV, Umriukhina PE, Rayevskyb KS (2004)

Further studies employing an ex-vivo skin model supported these findings, suggesting a notable increase in collagen IV synthesis at the dermal-epidermal junction when exposed to the optimized GHK-Cu and LMW HA mixture

Theoretically, the two compounds target completely different receptor systems (amylin receptors for cagrilintide, GLP-1/GIP/glucagon for retatrutide), which suggests they could work synergistically without receptor overlap

In reality, their skin never had a chance to adjust