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2023;381:e070630
Research suggests that 1-2 cycles per year may provide optimal longevity benefits, though Dr
Image Credit: Edugrafo / Shutterstock.com Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed the treatment of metabolic conditions such as obesity and diabetes
[5] Several biological mechanisms have been proposed in preclinical research that suggest plausible links between GLP-1 signalling and brain health: Neuroprotection : In laboratory and animal studies, GLP-1 receptor activation may protect neurons from oxidative stress and inflammation, both of which contribute to neurodegeneration [5] Neurogenesis : Animal studies suggest GLP-1 may promote the growth of new neurons in the hippocampus, a region essential for memory Reduction of amyloid plaques : Preclinical research indicates potential effects on beta-amyloid accumulation, a hallmark of Alzheimer's disease [5] Anti-inflammatory effects : Chronic neuroinflammation is implicated in various forms of dementia The connection between metabolic health and cognitive function provides additional rationale for investigating GLP-1 agents in dementia
It has shown promising results in obesity research , enhancing fat oxidation and improving lipid profiles while preserving lean muscle mass
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