Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
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Most of the research is focused on tendon healing, connective tissue recovery, inflammatory regulation, angiogenesis, and gastrointestinal protection
Studies document enhanced liver regeneration, improved wound healing, and restored satellite cell function in skeletal muscle following senescent cell clearance with the peptide
GHK-Cu promotes angiogenesis (new blood vessel formation), which raises theoretical concerns about supporting tumor growth, though the peptide also demonstrates documented anti-cancer gene expression effects
The mean change of 387.7 pg/mL was significant ( p = 0.0001 in Students t -test)