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Given that large, long-duration studies may be needed to demonstrate that a disease-modifying therapy is engaging the intended target and modifying disease progression, biomarkers can play an important role in phase 2 clinical trials to demonstrate proof of concept prior to initiating trials intended to demonstrate clinical benefit (Cummings, 2019

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In another study, GBs protective effect on melanocytes was shown to be dependent on activation of the Nrf-ARE pathway and downstream antioxidant genes, including NQO-1, SOD2 and haem oxygenase-1 [107]

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