An RCT (n=150) found that NAC (1,200 mg/day) plus clomiphene significantly improved ovulation rate and pregnancy rate compared to clomiphene plus placebo (Rizk et al., Fertil Steril, 2005) [58]
Mitigation strategies include frequent glucose monitoring when changes are made to insulin dosage, oral hypoglycemic medications, meal patterns, physical activity, and in cases of renal or hepatic impairment or hypoglycemia unawareness, with consideration for dose reduction
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Among these, the results of the SCALE study also demonstrated that the combination of Liraglutide 3.0 mg with lifestyle intervention resulted in maintaining the weight loss achieved with calorie restriction and promoted further body weight reduction over 56 weeks of treatment [151]