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People taking them often feel full sooner, eat less, and their bodies metabolize food more effectively

Charakida, M., Masi, S., Luscher, T

These drugs helped lower blood sugar through a few specific mechanisms: Increased insulin secretion from the pancreas Reduced how much sugar the liver put into the bloodstream (via reducing glucagon) Slowed gastric emptying, which makes glucose appear slower in the blood stream

The slowing of gastric emptying by GLP-1 is subject to rapid tachyphylaxis following chronic exposure, likely at the level of the vagus nerve

By now, it has been established that the primary function of GLP-1 and GLP-1RA is to modulate brain regions that regulate appetite by influencing the release of neurotransmitters and peptides involved in hunger and energy balance

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