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Lancet Respir

Abstract Metabolic reprogramming has been widely recognized as a hallmark of malignancy

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Furthermore, chronic overproduction of TGF1 from astrocytes and microglia leads to decreased pericyte coverage, facilitating vascular remodeling and suboptimal brain perfusion [187,188,189]

For patients without clear indication for b12 supplementation, using a compounded combination means paying extra for an additive that may provide no benefit