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The acetyl group attached to L-Carnitine appears to be crucial for these neurological benefits, as it allows the compound to more readily cross the blood-brain barrier and directly support brain cell metabolism

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CK, through the reduction of TGF1 and inhibiting its downstream pathway, RhoA/ROCK, ameliorates the G/F-actin ratio, which under glucotoxicity creates a barrier for GLP-1 secretion