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Under the if-all-adhere estimand, CagriSema produced 23.0% weight loss at 84 weeks, against 25.5% for tirzepatide
3 While the study could not prove the drugs directly caused these problems, the authors noted that rapid drops in blood sugar triggered by treatment could have contributed to the vision loss observed
Since a substantial portion of dAGEs in food is bound to proteins, this suggests that proteolytic digestion may play a role in their breakdown and some human digestive enzymes, such as elastase, trypsin, and chymotrypsin, are likely to contribute to the degradation of protein-bound dAGEs (105107)
Moras M, Hattab C, Gonzalez-Menendez P, Fader CM, Dussiot M, Larghero J, et al
doi: 10.1007/5584_2020_496
Oxidative Stress Evidence: Teranishi M, Uchida S, Nishio N, et al
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