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10.1038/s41392-023-01673-4 88 YangS.-H.XuR.-X.CuiC.-J.WangY.DuY.ChenZ.-G.et al (2018)

These symptoms can reduce food intake further, disrupt sleep, and contribute to dehydration, all of which exacerbate tiredness

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

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However, they work best as part of a comprehensive plan led by a medical professional