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Transcription factors NRF2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation
Mekala, K
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Leonurine, for example, exerts its anti-GA effects by suppressing COX-2 and LOX-5 expression, thereby reducing the prostaglandin E2 (PGE2) and LTB4 levels in synovial macrophages and diminishing neutrophil recruitment ( Fimbristylis aestivalis , which contains rosmarinic acid, catechin hydrate, and syringic acid, has inhibitory effects on COX-2 and effectively alleviates inflammatory responses (219), Vismodegib (220), New Pyrimidine-5-Carbonitriles (221), Sulfonamide-Pyrazole derivatives (222) and lariciresinol (223) exert regulatory effects on arachidonic acid metabolism by inhibiting COX-2, the specific drugs used are shown in Table 5
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