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In the overweight subgroup (BMI 25.029.9 kg/m), the live birth rate was 9.5% in semaglutide users and 17.9% in controls (OR = 0.48, 95% CI 0.201.15, p = 0.095), showing a non-significant downward trend
In the studies, 14.9% of total body loss was over the course of the study over 68 weeks
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The mechanisms may involve enhanced clearance of toxic protein aggregates and reduced production of pathological proteins, but translation to human disease remains uncertain
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Woreta, Johns Hopkins Medicine, Baltimore, MD and Saleh A Alqahtani, Johns Hopkins University School of Medicine
