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The detailed search strategy is described in Supplementary Table 4

This increases oxidative deamination of amino acids, generating ammonium, which is mostly transformed into urea ( Madsen, 1983 )

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The exposure achieved with this dose in humans, however, might be too low to reach a sufficiently high GCGR occupancy as observed in this study

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In addition, there are potentially other less-characterized pathways involving NLRP6, NLRP7, NLRP12, RIG-I, and IFI16