Clinical studies investigating oxidative stress in depression have demonstrated that a key characteristic of oxidative stress in depression is the diminished antioxidant capacity and inadequate blood levels of antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT)
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Collectively, these trials reflect a strategic shift toward precision therapeutics that are specifically engineered to circumvent or dismantle key resistance mechanisms, whether through selective degradation, allosteric blockade, metabolic disruption or immunologic remodeling
Small particles can easily penetrate ocular barriers and reach sensitive tissues, while specific shapes may affect their cellular uptake and biodistribution [258]
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