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It works through inhibition of the TREK-1 potassium channel, a mechanism that enhances neuronal excitability and promotes serotonergic transmission

Research parameters include absorption kinetics, systemic distribution, first-pass metabolic avoidance, and potential olfactory or trigeminal transport pathways to the central nervous system

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Serotonin Syndrome in Children and Adolescents Exposed to Selective Serotonin Reuptake Inhibitors A Review of Literature