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Definitions and inclusion/exclusion criteria Concerning ES: ES was defined as stress during early-life, from conception up to up to 18 years of age (human studies) or weaning (preclinical studies)

Rotating injection sites significantly reduces the frequency and intensity of these reactions

This is a tolerance-building dose, not a therapeutic one

For a comprehensive approach to eating during treatment, review our guide on foods to eat while on semaglutide

Strata are defined as trial-level cardiovascular risk (SURPASS-4 forms one stratum, and all other trials form one stratum)