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A study noted elevated aminotransferases in seven of 11 children treated for aHUS, with one case of severe elevation leading to treatment discontinuation

The tumor tissues were incubated overnight at 4C in the following IHC stains, then incubated in secondary antibodies: P-gp (1:500)

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Moreover, the addition of -ketoglutarate (-KG), a metabolite derived from glutamate, effectively restored the viability of cancer cells with elevated levels of SLC7A11 during glucose deprivation, indicating a potential role for exported glutamate in promoting cancer cell death (59)