These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia
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But there is very limited evidence that glutathione can change skin pigment
A 2025 systematic review examined all published literature on the compound, identifying 544 total articles published between 1993 and 2024
Review article: smoking cessation as primary therapy to modify the course of Crohn's disease