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This study reported a similar incidence of MCMs following exposure to insulin (7.8%, n=5078) vs other antidiabetic agents: GLP-1 RAs (8.3% n=938), sodium-glucose co-transporter-2 inhibitors (SGLT2i) (7.0% n=335), sulfonylureas (9.7%, n=1362) and dipeptidyl peptidase 4 (DPP-4) inhibitors (6.1%, n=687)
In fact, the glucagon receptor component theoretically supports energy expenditure through thermogenesis in brown fat tissue, which could partially offset the fatigue from caloric restriction
Weight-loss medications have come a long way from the amphetamine-based rainbow pills of the 1950s and 60s to the infamous Dexatrim of the 80s and the fenphen era of the 90s
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