Interchangeability and the Automatic Substitution Question A biosimilar can be approved as biosimilar without being designated interchangeable. Interchangeability requires additional evidence that the biosimilar can be substituted for the reference biologic without increased risk compared to using the reference product alone, and without involvement of the prescribing physician [41]
Tirzepatide may lead to greater weight loss for some patients because it targets both GLP-1 and GIP pathways
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For example, once-weekly exenatide (PLGA microspheres) commonly caused small injection-site nodules or bumps
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This cardiovascular outcomes trial of semaglutide versus placebo in patients with type 2 diabetes at high cardiovascular risk revealed an unexpected finding: patients receiving semaglutide experienced a statistically significant increase in diabetic retinopathy complications (hazard ratio 1.76, 95% CI 1.112.78, p=0.02)