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A post-hoc analysis of SURMOUNT-1 (Rubino et al., Diabetes, Obesity and Metabolism , 2023) found that patients over 65 tolerated tirzepatide better when titration intervals were extended to 6 weeks
IGF-1 LR3 also inhibits protein breakdown and suppresses the expression of genes that drive muscle atrophy
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That makes it even more important to choose nutrient dense foods during each eating window to avoid falling short on calories, protein, or important nutrients
You will see marketing that implies small, steady doses preserve lean mass
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