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Researchers are evaluating its potential to benefit patients with osteoarthritis (7)

This has driven interest in alternative mechanisms and combination approaches that might deliver comparable efficacy with improved side effect profiles

10.1038/nature17976 215 OwnbyC

Modulators of the JAK/STAT axis and cAMP/CREB activators (e.g., rolipram and forskolin) similarly attenuate pathogenic cytokine signaling and support Treg responses, aligning with the immunological signature of exercise in EAE [257, 259]