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Jolanta Pekala, Bozena Patkowska-Sokola, Robert Bodkowski, Dorota Jamroz, Piotr Nowakowski, Stanislaw Lochynski, Tadeusz Librowski
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Retatrutide vs Tirzepatide Tirzepatide (Mounjaro/Zepbound) adds GIP receptor activation to GLP-1, representing an intermediate step between Semaglutide and Retatrutide
GLP-1RA treatment enhances IL-10 secretion by M2 macrophages (133), an effect that exhibits strong concentration dependence: Low IL-10 concentrations may facilitate tumor immune evasion, whereas high concentrations promote CD8+ T cell proliferation, activation and cytotoxicity (134)
This system is further modulated by peripheral hormones such as leptin (and, to a lesser extent, insulin), which enhance Pomc expression and suppress Agrp expression, thereby promoting satiety [53, 54]
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