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Gonzlez JA, Reimann F, Burdakov D
and participation on Advisory Boards for Novo Nordisk and Eli Lilly and Company
The STEP trials found that people who stayed on semaglutide for two years maintained their weight loss and continued to show improvements in HbA1c, fasting glucose, triglycerides, and inflammatory markers
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This explains why clinicians start patients on lower doses and titrate upward over months the drug is still accumulating during those early weeks
Rigorous, long-term prospective trials in asymptomatic, high-risk populations such as individuals with type 2 diabetes, obesity, or APOE4 carrier status are required to definitively validate or refute this hypothesis
