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These tissue regeneration research findings have implications for regenerative medicine approaches, understanding stem cell aging, and developing interventions that restore the body's natural repair capacity diminished by senescent cell accumulation

NAD+ levels decline with age , and supplementation with NAD+ has been shown to have beneficial effects on health and longevity

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The authors would like to acknowledge the research team in the Department of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan Malaysia, for the technical support throughout this review

As a research tool, BPC-157 does not correspond to any known endogenous receptor ligand but has demonstrated interactions with several signaling systems in preclinical models

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