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Using recommended dosing conditions for oral semaglutide, mean bioavailability was estimated at approximately 0.8% (0.795% [95% confidence interval 0.7360.864]) (Table 1 of the ESM)

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Future quality improvement initiatives should aim to limit PPI use in patients with cirrhosis to those with clinical indications and educate prescribers on limiting PPI exposure by using the lowest dose and shortest frequency

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