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Although the clinical effect of l-asparaginase clearly indicates that asparagine is crucial for tumor survival and metastasis 52 , the importance of asparagine beyond protein synthesis and the mechanism by which asparagine supplementation enhances glutamine-associated metabolism are less well understood
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10.1134/S0006297920080052 73 KangR.ZengL.ZhuS.XieY.LiuJ.WenQ.et al (2018)
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It serves as a substrate for sirtuins (SIRT1-7), PARP enzymes, and CD38, making it a subject of significant interest in ageing biology, metabolic research, and DNA repair studies
