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2.3 Neuroinflammation and cognitive dysfunction in diabetes Diabetes, as a chronic metabolic disorder, induces a chronic inflammatory state that damages the central nervous system

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When these proteins are abnormally expressed, the overload cytosolic free ferrous iron leads to intracellular ROS accumulation via the Fenton reaction, which eventually promotes lipid peroxides formation and ferroptosis occurrence (186)

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Annu Rev Biochem 72:249289