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The effect has been characterized as partially dependent on dietary fat content and not strictly correlated with baseline obesity in rats on free-choice diet protocols

In preclinical research, GH and IGF-1 are themselves anabolic and regenerative factors, suggesting potential complementarity

doi: 10.1210/endo-114-3-957

It creates inequitable access based on employment status, geography, and income rather than medical need

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In the STEP clinical trial program, weekly subcutaneous semaglutide 2.4 mg produced mean weight loss of 14.9% at 68 weeks in the STEP 1 trial