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Although transient elevations in liver metabolic enzymes occurred during treatment, subsequent abdominal ultrasound examinations revealed no hepatic abnormalities
NAD + homeostasis is not only regulated at the systemic level, but the pathways involved in synthesis and consumption also present dynamic and complex cellular locations and regulation
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EV dose should not be defined by protein content or particle number alone
Therefore, it can be applied directly as a topical (graft washing), oral supplement, subcutaneous/intravenous injection, or a combination of multiple routes (similar to the approach applied in our study)
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