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10.1007/s11695-017-2980-3 6
As discussed by Gale and Foy (see page 939, in this issue) the interplay between HCV and innate cellular antiviral pathways may be a major intracellular determinant of HCV tropism
Prokinetic agents like metoclopramide present a theoretical option but should be used cautiously given potential adverse effects (including tardive dyskinesia with use beyond 12 weeks) and the counterintuitive nature of accelerating gastric emptying while using a medication that intentionally slows it
Some studies found that it could increase HDL (good) cholesterol while lowering LDL (bad) cholesterol
Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
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