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Snchez-Tapia et al, 2020
While both agents struggled with the inherent GI burden typical of GLP-1RAs, efpeglenatides limitations were largely dose-related and within manageable expectations, whereas taspoglutides combination of severe immunogenicity and hypersensitivity reactions rendered it clinically unviable
Dual agonists are thought to be more effective at lowering blood sugar and weight loss than GLP-1 RAs alone
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That is not what we do
Myeloperoxidase (MPO), released from activated neutrophils, produces reactive oxidants that lead to low-density lipoprotein (LDL) oxidation, endothelial dysfunction, and atherosclerotic plaque formation [35]
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