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Research demonstrates activity in gene regulation related to collagen synthesis, antioxidant defense, and anti-inflammatory pathways [3] [4]

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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

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Novagen) and purified using nickel agarose beads

Complete immobilization causes bone loss while appropriate loading stimulates strengthening