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That non-responder pattern is recognised in the clinical literature and is part of why UK guidance frames pharmacological treatment as one tool within a broader weight-management approach rather than a guarantee

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To achieve this, ES cells have higher antioxidant defense mechanisms, resulting in a lower mutational frequency than differentiated cells [119, 120]

Transient expression assays in protoplasts confirmed that phospho-mimetic mutants exhibit higher transcriptional activation of target promoters compared to wild-type protein (39)