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Folate tolerance varies Folic acid, folinic acid and methylfolate may help selected patients but may worsen anxiety, agitation or sleep in susceptible undermethylators
Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels
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"Glutathione production requires methylation." From this perspective, increasing glutathione from external sources (food and supplements) can take the pressure off the methylation cycle and glutathione production
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