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It's the first committed step in fatty acid synthesis, is rate-limiting for the pathway, and is tightly regulated

Other possible effects include injection-site reactions, itching, rash, weight gain, swelling, and changes in potassium levels

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Medullary thyroid cancer history and MEN2 are firm contraindications GLP-1 medications, particularly semaglutide, are not recommended for these patients due to thyroid C-cell tumor risk

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