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The insulinotropic impacts of secreted GLP-1 are facilitated by its interaction with GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR)

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Clinical studies suggest that tirzepatide produces greater average weight loss than semaglutide in many patients

GLP-1 has multifaceted actions, including glucose-induced stimulation of insulin biosynthesis and secretion, inhibition of glucagon secretion, regulation of gene expression, trophic effects on cells, inhibition of food intake, and slowing of gastric emptying