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Stroke disrupts the hypothalamic-pituitary axis, often producing hormonal imbalances that further impair recovery
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At ~5382 Da, FOXO4-DRI is above the typical renal filtration threshold (~60 kDa for globular proteins, but much lower for linear peptides), suggesting renal clearance may contribute to elimination
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Although, cells have antioxidant defense system (antioxidant enzymes) to encounter harmful effects of free radicals
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