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Among the targets of p53 activity are sestrins (sestrin 1 and 2) that induce the activity of peroxiredoxins, increasing the impact of the cellular antioxidant array 26

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Clinical data also demonstrate a positive correlation between C

Pro-inflammatory cytokines, including IL-6, IL-1, and TNF-, promote M1-type TAM formation, inhibit iron release into the tumor immune microenvironment (TIME), and exert anti-tumor effects (77)